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. 2021 Dec 3;12:7065. doi: 10.1038/s41467-021-26703-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — (Data from all 2832 ADNI/BLSA participants) a Cumulative incidence of pattern progression. The line styles indicate the diagnosis at baseline. 95% confidence intervals are shown with estimated cumulative incidence curves as centres. b Annual atrophy rate in selected GM regions along different paths. Data within 3 years before pattern change or last follow-up point (for stable P1 participants (P1-P1)) were utilized and random intercept mixed effect model with time as fixed effect was used to derive annual volume change rate with respect to baseline volume. Data are presented as estimated coefficient of time variable ±standard error. (PHC Parahippocampal gyrus, ERC Entorhinal cortex) Source data are provided as a Source Data file.