Fig. 3.

Amino acid sequence alignment of the LRRNT motif and the secondary structures identified from known structures of five SLRPs and FLRT3. ^aChondroadherin like protein (1) and (2) indicate the first and the second LRR domains, respectively. Shaded areas indicate the secondary structure elements; light blue indicate polyproline II helix conformations, yellow b-turns in which the first residue and the last residues show residue i + 1 and i + 2, respectively, pink b-strands. Cysteine residues are shown in white text over light blue, pink, or black background. Underlined residues “A”, “M”, and “E” are “S”, “L”, and “D” in human biglycan and decorin, respectively. Bos taurus biglycan (PDB ID: 2FT3); Bos taurus decorin (PDB ID: 1XKU); Human fibromodulin (PDB ID: 5MX0); Human osteomodulin (PDB ID: 5YQ5); Human chondradherin (PDB ID: 5LFN); FLRT3 (PDB ID: 6JBU)