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. 2021 May 27;11(11):3465–3480. doi: 10.1016/j.apsb.2021.05.027

Figure 6.

Figure 6

SW33 induced autophagy of GBM cells by regulating PI3K/AKT and AMPK signaling pathways. KEGG pathway analysis of differentially expressed genes at 24 (A) and 48 h (B). (C) and (D) Protein levels of p-PI3K, PI3K, p-AKT, AKT, p-AMPK, AMPK in SW33-treated U87 and U251 cells detected by Western blotting. The ratio of p-PI3K/PI3K and p-AKT/AKT decreased while p-AMPK/AMPK increased. (E) Diagram of autophagy induced by SW33 via PI3K/AKT/mTOR and AMPK/mTOR signaling pathways. Experiments were performed in triplicate.