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In vitro antitumor mechanisms. (A) Intercellular delivery of DOX from treated SKOV3 cells to fresh SKOV3 cells, cell nuclei was stained with DAPI (blue fluorescence), DOX concentration: 1 μmol/L, scale bar = 200 μm. (B) O2 detection of hypoxic SKOV3 cells by [Ru (dpp)3]Cl2 probe, scale bar = 200 μm. (C) Immunoblot of endogenous HIF-1α and its downstream P-gp, CTGF, collagen I after different treatment (1) control; (2) CaO2/MnO2-MS; (3) DOX; (4) DOX-CaO2/MnO2-MS under hypoxia.
