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(A) In vitro penetration of DOX into the MCTS after incubation with different formulations for 24 h, DOX concentration: 2 μmol/L, scale bar = 200 μm. (B) MCTS inhibition effects, DOX concentration: 4 μmol/L, scale bar = 200 μm. (C) The volume change of MCTS. Data are presented as mean ± SD, n = 5.
