Table 2.
Parameter (Male) |
Vehicle (0.3%CMC) |
Cisplatin (5 mg/kg) |
TK (500 mg/Kg) |
TK (1000 mg/Kg) |
---|---|---|---|---|
Creatinine (mg/dL) | 0.83 ± 0.02 | 1.183 ± 0.16∗ | 0.81 ± 0.01≠ | 0.80 ± 0.0≠ |
BUN (mg/dL) | 14.02 ± 0.6452 | 23.02 ± 1.644∗∗ | 20.12 ± 2.53 | 15.17 ± 0.716≠ |
Uric Acid (mg/dL) | 1.75 ± 0.10 | 1.76 ± 0.12 | 1.35 ± 0.06∗≠ | 1.48 ± 0.06 |
Sodium (mmol/L) | 120.7 ± 0.84 | 118.7 ± 1.11 | 116.0 ± 1.29 | 119.0 ± 1.50 |
Potassium (mmol/L) | 13.82 ± 0.46 | 15.02 ± 0.44 | 15.55 ± 0.30 | 15.67 ± 0.75 |
Chloride (mmol/L) | 106.7 ± 0.33 | 108.2 ± 0.47 | 108.3 ± 0.55 | 108.2 ± 0.47 |
Calcium (mmol/L) | 1.73 ± 0.02 | 1.73 ± 0.02 | 1.85 ± 0.02 | 1.917 ± 0.122 |
Total Protein (g/dL) | 7.08 ± 0.03 | 6.91 ± 0.18 | 7.06 ± 0.03 | 6.93 ± 0.05 |
Values presented as mean ± SEM; n = 06; One-way ANOVA; ∗ = p < 0.05 vs. control ∗∗ = p < 0.01 vs. control, ≠ = p < 0.05 vs. Cisplatin control.