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. 2021 Nov 3;25(23):10939–10949. doi: 10.1111/jcmm.16998

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© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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BTZ modulating the differentiation of Th17/Treg by facilitating the expression of Atg5. * p < 0.5; # p < 0.05. (A) Atg5, Atg7, Atg12 expression in the AMR‐Veh group and the AMR‐BTZ group. (B‐D) The relative proportions of Treg and Th17 in the AMR‐Veh group, the AMR‐BTZ group and the AMR‐BTZ‐siAtg5 group. (E) HE staining and C4d staining of kidneys in the AMR‐Veh group, the AMR‐BTZ group, and the AMR‐BTZ‐siAtg5 group. (F) Histology score of kidney according to Banff criteria. (G) The serum level of DSAs in the AMR‐Veh group, the AMR‐BTZ group and the AMR‐BTZ‐siAtg5 group. (H) The survival curves of rats in the AMR‐Veh group, the AMR‐BTZ group and the AMR‐BTZ‐siAtg5 group