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. 2021 Nov 5;25(23):10950–10960. doi: 10.1111/jcmm.17013

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© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Significantly enriched KEGG pathways in three cohorts by GSEA. Genetic alterations of the 12 ferroptosis‐related genes. (A,B,C) Top 20 representative KEGG pathways in HR group in the training cohort, the TCGA‐LAML cohort and the GSE37642‐570 cohort, respectively (p < 0.05). (D) Genetic alterations of the 12 ferroptosis‐related genes in CCLE, obtained from the cBioportal for Cancer Genomics (http://www.cbiop ortal.org/). (E) The protein‐protein interactions between the model related proteins and the other proteins. The model related proteins are shown in blue circles and the size of which is determined by the number of interacting proteins. ENPP2 has no known interactions with other proteins