Table 2.
The effect of hUSCs on diabetic rats
| Variable | Normal | Diabetes | Diabetes + hUSCs‐Exo control | Diabetes + hUSCs‐Exo miR‐16‐5p |
|---|---|---|---|---|
| Glu (mmol/L) | 5.52 ± 0.47 | 25.45 ± 3.264 | 20.53 ± 2.17*, # | 16.34 ± 1.33*, # |
| KW (g) | 1.35 ± 0.15 | 2.58 ± 0.374 | 2.12 ± 0.27*, # | 1.73 ± 0.16*, # |
| BW (g) | 362.00 ± 15.35 | 242.54 ± 12.234 | 251.85 ± 14.244 | 253.45 ± 8.754 |
| BUN (mmol/L) | 8.24 ± 0.78 | 18.72 ± 1.254 | 15.35 ± 1.01*, # | 12.01 ± 0.84*, # |
| Scr (μmol/L) | 66.47 ± 5.72 | 99.27 ± 7.574 | 87.68 ± 6.54*, # | 78.23 ± 3.87*, # |
| CCR (mmol/L) | 1.05 ± 0.14 | 2.25 ± 0.254 | 1.70 ± 0.11*, # | 1.41 ± 0.18*, # |
| Ucr (μmol/L) | 89.46 ± 9.11 | 423.37 ± 45.484 | 245.82 ± 27.48*, # | 287.37 ± 24.99*, # |
| Upro (mg/24 h) | 6.47 ± 0.77 | 35.57 ± 4.374 | 14.85 ± 1.66*, # | 19.37 ± 1.77*, # |
Measurement data were expressed as mean ± standard deviation, data among multiple groups were analysed using one‐way analysis of variance, and the experiment was repeated three times.
Abbreviations: BUN, blood urea nitrogen; BW, body weight; CCR, creatinine clearance rate; Glu, blood glucose; hUSCs, human urine‐derived stem cells; KW, kidney weight; miR‐16‐5p, microRNA‐16‐5p; Scr, serum creatinine; Ucr, urine creatinine urine protein; Upro, urine protein.
*
P < .05 vs the normal group;
#
P < .05 vs the diabetes + hUSCs‐Exo control group.