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. 2021 Dec 4;21:100198. doi: 10.1016/j.mran.2021.100198

Figure 4.

Figure 4:

Predicted effect of a combination of unfractionated heparin (UFH) and ZnOT which affect virus binding to the host cell on dose-response for SARS-CoV-2 infection (Equation 1 with ppfu = 10−4; Fv = 1, pentry = 0.5, pvirogenesis = 1, pbudding = 1 in Equation 2) with FB calculated from Equation 8 with Ka_virus_T = 3.53 × 1017 M−1 as estimated for SARS-CoV-2 (Table 3). No UFH and no ZnOT (solid line); UFH alone at concentration of 2.1 μM (IC50) (dashed line) and at concentration of 62.5 μM (1,000 μg/cm3) (dash single dot line) with KVI = 0.73 × 10−10 M (for heparin binding to SARS-CoV-2 SGP trimer (Kim et al 2020)); ZnOT alone with Ka_virus_T = 5.76 × 1012 M−1 as estimated for SARS-CoV-2 complexed to ZnOT (see text) (dotted line); and UFH at concentration of 2.1 μM with ZnOT acting synergistically (dash double dot line).