Table 1.

Parameters for a thermodynamic equilibrium dose-response model for infection by a respiratory virus (Gale 2020a) together with possible antiviral interventions.

Parameter in Equation 2	Description	Possible interventions
Fv	Fraction of virus in lung mucus not bound to mucin, i.e. free	Blocking of viral neuraminidases and esterases if present. Not present on SARS-CoV-2
ppfu	Probability that a given virion (represented in the exposure as a viral RNA copy) is itself capable of initiating infection in a cell. In effect the inverse of the number virions in a plaque-forming unit.	N/A
FB	Fraction of virus dose bound to lung cells	Either a competitive inhibitor such as heparin that blocks ACE2 binding with a low KVI or an irreversible inhibitor that makes ΔSa_immob more negative. Possible synergistic effects on FB in combination.
pentry	Probability that a virion bound to cell surface enters that cell	Block cleavage of SGP to prevent viral membrane fusion.
pvirogenesis	Probability virus replicates within cell after entry and progeny virions are assembled.	Target viral main protease (Mpro). Major focus of research for SARS-CoV-2 (Zhang et al 2020).
pbudding	Probability progeny virions exit the infected cell