Table 1.
Demographics and Characteristics of Patients
| Variables | LC(n = 1090) | LC-VTE (n = 173) | P value |
|---|---|---|---|
| Age-years | 68.5 (47.6–86.3) | 72.2 (51.5–88.6) | 0.723 |
| Sex (female/male)-% | 43.0/57.0 | 46.8/53.2 | 0.915 |
| BMI-kg/m2 | 21.9 (17.5–27.3) | 29.6 (24.3–34.7) | 0.013 |
| Smoking (Y/N)-% | 40.1/59.9 | 50.9/49.1 | 0.009 |
| Smoking index-pack/year | 33.6 (21.3–45.9) | 47.3 (30.6–63.7) | 0.001 |
| Histopathology-no.(%) | |||
| Adenocarcinoma | 673 (61.7) | 109 (63.0) | 0.537 |
| Squamous | 269 (24.7) | 40 (23.1) | 0.941 |
| SCLC | 123 (11.3) | 17 (9.80) | 0.713 |
| Others | 25 (2.30) | 7 (4.10) | 0.025 |
| Stage-no.(%) | |||
| Stage I | 199 (18.3) | 3 (1.70) | < 0.001 |
| Stage II | 227 (20.8) | 33 (19.1) | 0.985 |
| Stage III | 257 (23.6) | 44 (25.4) | 0.836 |
| Stage IV | 407 (37.3) | 93 (53.8) | 0.001 |
| High or intermediate | |||
| C-PTP(Y/N)-% | 45.2/54.8 | 74.6/25.4 | < 0.001 |
| D-dimer-mg/L | 3713 (2336–5369) | 1331 (854–1776) | < 0.001 |
| Platelet- × 109/L | 387 (226–543) | 252 (157–357) | 0.001 |
| Hemoglobin-g/L | 97 (83–114) | 109 (91–127) | 0.573 |
| WBC- × 109/L | 13.1 (7.62–18.6) | 7.73 (4.38–11.1) | 0.001 |
| Chemotherapy(Y/N)-% | 65.8/34.2 | 94.2/5.8 | < 0.001 |
| PS score-point | 1.35 (0.66–2.25) | 2.31 (1.23–3.47) | 0.005 |
| Metastasis(Y/N)-% | 37.3/62.7 | 53.8/46.2 | 0.001 |
| Previous VTE(Y/N)-% | 9.9/90.1 | 17.9/82.1 | 0.001 |
| Vascular/lymphatic compression(Y/N)-% | 70.1/29.9 | 90.8/9.2 | < 0.001 |
| Anti-hormonal or anthracycline therapy(Y/N)-% | 2.0/98.0 | 1.7/98.3 | 0.896 |
| Time since cancer diagnosis≤6 months(Y/N)-% | 49.8/50.2 | 52.6/47.4 | 0.916 |
| CVC(Y/N)-% | 3.9/96.1 | 9.8/90.2 | < 0.001 |
| Cardiovascular risk factors(Y/N)-% | 15.0/85.0 | 29.5/70.5 | < 0.001 |
| Recent hospitalization (Y/N)-% | 66.5/33.5 | 97.7/2.3 | < 0.001 |
Note: LC: Lung Cancer, LC-VTE:Lung Cancer and Venous Thromboembolism, no.:number, BMI: Body Mass Index, kg/m2: kilogram/meter2, Y/N:Yes/No, SCLC: Small Cell Lung Cancer, C-PTP: Clinical Pretest Probability, mg/L:milligram/liter, L:liter, WBC: White Blood Cell, PS: Performance Status, VTE:Venous Thromboembolism, CVC: Central Venous Catheter