Table 4.

Diagnostic performance of the indices for the differentiation of F3 and F4 from lower stages

Indices	AUC (95% CI)	P value	Optimal cut-off	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	DA (%)
APRI	0.923 (0.876–0.970)	< 0.001	0.702	84.1	88.2	66.1	95.3	87.3
FIB-4	0.913 (0.868–0.958)	< 0.001	1.19	97.7	72.7	49.4	99.2	78.0
AST/ALT	0.720 (0.631–0.808)	< 0.001	0.94	61.4	77.0	42.2	87.9	73.7

AST aspartate aminotransferase, ALT alanine aminotransferase, CAP controlled attenuation parameter, APRI AST to platelet ratio index, FIB-4 fibrosis-4, AUC area under the curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value, DA diagnostic accuracy