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. 2021 Dec 4;21:644. doi: 10.1186/s12935-021-02268-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — lncRNA H19 regulates the sensitivity of NSCLC cells to X-ray and carbon ion irradiation. A Differential lncRNA expression was found between A549 and radioresistant (A549-R11) cells. B The OS of NSCLC patients with different expression levels of lncRNA H19 after radiotherapy. C The transfection efficiency of H19 was measured by qRT–PCR. D Colony formation ability after H19 knockdown and irradiation. E Cell viability after H19 knockdown and irradiation was measured by a CCK-8 assay. F Flow cytometric analysis of apoptosis after H19 knockdown and irradiation. The data are presented as the mean ± SD values. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the control group