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. 2021 Dec 4;21:644. doi: 10.1186/s12935-021-02268-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — WNK3 modulated the radiosensitivity of NSCLC cells and affected the P38 signaling pathway. A Colony formation ability after WNK3 knockdown and irradiation. B Cell viability after WNK3 knockdown and irradiation was measured by a CCK-8 assay. C Flow cytometric analysis of apoptosis after WNK3 knockdown and irradiation. D The levels of (Top) cleaved caspase3 and (Bottom) PARP (85 kDa, cleaved; 115 kDa, precursor) in H460 cells after WNK3 knockdown and irradiation. The si-NC group was set to “1.00”. GAPDH was used as the control. E The expression of Bax and Bcl-2 after WNK3 knockdown and irradiation. The si-NC group was set to “1.00”. GAPDH was used as the control. F The expression of p-p38 in H460 cells after WNK3 knockdown and irradiation. The si-NC group was set to “1.00”. GAPDH was used as the control. G Cell viability after transfection with the NC or H19 overexpression plasmid or cotransfection with the H19 overexpression and miR-130a-3p mimic and treatment with irradiation was tested using a CCK-8 assay. The data are presented as the mean ± SD values. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the control group