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. 2021 Dec 4;21:648. doi: 10.1186/s12935-021-02320-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — a Volcano plot of DEGs, including 1355 upregulated genes and 1484 downregulated genes. The threshold for the X axis was Log2fc ≥ 1 and Log2fc ≤ -1, and the threshold for the Y axis was P-value < 0.05. b GO enrichment analysis of DEGs revealed enriched biological process terms. c GO enrichment analysis of DEGs revealed enriched cellular component terms. d GO enrichment analysis of DEGs revealed enriched molecular function terms. e Top 5 enriched terms in the BP, MF and CC categories. f The top ten KEGG signaling pathways (KEGG analysis) enriched with the DEGs