Table 1.

Summary of PRINCESSE healthcare package per protocol visit

Time since inclusion (MO) W: week/M: month		M0	W2	M3	M6	M9	M12	M15	M18	M21	M24
Initial screening (at inclusion)	HIV testing	✓
	HBsAg testing	✓
HIV prevention (if HIV-)	HIV testing			✓	✓	✓	✓	✓	✓	✓	✓
	Creatinine (if PrEP)	✓		✓	✓	✓	✓	✓	✓	✓	✓
	HIV PrEP (TDF/FTC) (if eligible)		✓	✓	✓	✓	✓	✓	✓	✓	✓
	At PrEP interruption (if AgHBs + or isolated HBcAb)	ALAT/ASAT (every 3 months) + HBV viral load if sign of hepatitis B reactivation
	HIV post-exposure prophylaxis	when needed
HIV care (if HIV+)	Antiretroviral treatment	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓
	CD4 and viral load (if HIV+)	✓			✓		✓		✓		✓
HBV prevention (if HBsAg-)	HBsAb testing	✓
	HBcAb testing	✓
	HBV vaccination (if HBsAb- et HBcAb-)	3 × 1 doses if HIV- (M0, M1, M6), 4 × 2 doses if HIV+ (M0, M1, M2, M6)
HBV care (if HBsAg+)	HBeAg testing	✓
	Creatinine (if on TDF)	✓		✓	✓	✓	✓	✓	✓	✓	✓
	ALT/AST/Platelets	✓			✓		✓		✓		✓
	Antiretroviral treatment (TDF/FTC) (according to FIB-4 level and creatinine clearance level)		✓	✓	✓	✓	✓	✓	✓	✓	✓
	HBV viral load	✓					✓				✓
STI screening and care	Syndromic STI screening	✓		✓	✓	✓	✓	✓	✓	✓	✓
	Systematic STI testing (Chlamydia PCR + Gonorrhea PCR + Syphilis rapid test)	✓					✓				✓
	Dysplasia testing (+ treatment when necessary)	✓					✓				✓
	STI treatment	when needed
Pregnancy screening and contraception	Pregnancy test	✓		✓	✓	✓	✓	✓	✓	✓	✓
	Contraception (pills, injection or implant according to patient’s choice)	✓		✓	✓	✓	✓	✓	✓	✓	✓
	Emergency pill	when needed
Other	Condom and lubricating gel	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓
	Identification of addiction (tobacco, alcohol, drugs) and referencing when necessary			✓		✓		✓		✓