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. 2021 Dec 4;20:158. doi: 10.1186/s12943-021-01457-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Differential expression profile of circRNAs in human gastric cancer (GC) and adjacent normal tissues. a The numbers and ratios of circRNAs originating from different regions of the genome. b The number of circRNAs and back-spliced reads identified. X-axis: the backspliced reads of circRNAs detected in this study. Y-axis: the number of circRNAs. c The chromosome distribution pattern of circRNAs shows no difference between the cancer and normal groups. d The length of the majority of the circRNAs is less than 1500 nucleotides (nt). e The dendrogram shows the relationship between the samples and the differentially expressed circRNAs. The differential expression in the normal and cancer samples was clearly distinguishable. f The workflow used to identify functional circRNAs with coding potential in GC