Figure 1.

Basic structure of liposome and structural modification of liposomes for infiltration to brain.

Ligand-targeted liposome: Ligand like antibody or peptides are bound on to surface of liposome directly or through polyethylene glycol chain to improve the delivery of drug to the brain by targeting the endothelial receptor at the brain leading to transcytosis. Cationic liposomes: Positively charged liposomes causing electrostatic interface between polyanions of the blood-brain barrier and positive charge on liposomes thereby facilitating absorbent facilitated endocytosis. Theranostic Liposomes: Multifunctional liposomes with ability to carry drugs as well as noninvasive contrast agents for diagnosis useful as drug delivery system and an existing disease monitoring tool.