Table 1.

Comparison of modified liposomes

Other liposomes	Advantage	Disadvantage
Immunoliposomes
Liposomes loaded with a drug are conjugated with monoclonal antibody that is set to target specific cells.	Selective drug targeting to cancer cells to target tumor specific antigen	Induction of immunogenicity
	Modification of the exterior of the liposomes increases affinity to the targeted tumor cells and the antibody enhanced the therapeutic index	Rapid clearance due to non-specific uptake by the reticuloendothelial system (RES)
		Low therapeutic efficiency due to reduced cancer cell penetration because of binding site barrier effect or receptor downregulation
		lack of internalization and poor stability while in circulation
Virosomes
Noncovalent combination of a liposome and a fusogenic viral envelope replication	Efficient cell binding, internalization and drug release to cytoplasm	Toxicity, stability leakiness and Immunogenicity
	Efficient intracellular delivery of various drugs, cytotoxic drugs, toxoids, and various antigens
Gene based liposomes
Consist of positive charge liposomes and a DNA or functional gene	Suitable for gene delivery	Low efficiency gene transfer and expression in vivo as compared to viral vectors
		Clearance of cationic liposomes through the endosomes
	Overcomes challenges associated with mutagenicity and immunogenicity of virosomes	Lack of targeting to a specific tissue
		Toxicity of cationic lipids

Information in Table 1 is a summary of the studies from Çağdaş et al. (2014), Onodera et al. (2014), Kuo and Tsao (2017), Elsana et al. (2019), Harilal et al. (2019), and Mourtas et al. (2019).