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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Br J Pharmacol. 2021 Jun 21;178(19):3905–3923. doi: 10.1111/bph.15531

Figure 2. BW-031 inhibition of human Nav1.1 and Nav1.8 channels.

Figure 2.

(a) Use-dependent inhibition of hNav1.1 channels by 100 μM intracellular BW-031 (red) compared to recording with control intracellular solution (black). Nav current was evoked by 20-ms depolarizations from −100 to 0 mV at the indicated frequencies. (b) Collected results for hNav1.1 inhibition by 100 μM intracellular BW-031 (red, n=5) compared with control (black, n=5) and with inhibition of hNav1.7 (n=6, replotted from Figure 1e). (c) Use-dependent inhibition of hNav1.8 channels by 300 μM intracellular BW-031 (red) compared to recording with control intracellular solution (black). Nav current was evoked by 20-ms depolarizations from −70 to 0 mV at the indicated frequencies. (d) Collected results (mean±SD) of hNav1.8 inhibition by 300 μM intracellular BW-031 (red, n=5) compared with control (black, n=5) and with inhibition of hNav1.7 by 100 μM BW-031 (n=6, replotted from Figure 1e). Asterisks indicate P<0.05.