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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Br J Pharmacol. 2021 Jun 21;178(19):3905–3923. doi: 10.1111/bph.15531

Figure 5. BW-031 produces long-lasting analgesia in a mouse paw UV-burn model and has no effect on sensory or motor function with perisciatic injection in naïve mice.

Figure 5.

(a) Von Frey measurements of hindpaw mechanical sensitivity in male mice after plantar UV-burn and intraplantar injection of vehicle, 2% QX-314 or 2% BW-031. N=10 mice per group. Bars represent mean±SD for each condition. Asterisks indicate P<0.05.

(b) Toe spread assay of motor function in naïve male mice after perisciatic injection of 0.5% lidocaine, 0.5% QX-314 or 0.5% BW-031. Lidocaine produces robust block of motor function in naïve mice at 5 min with recovery at 60 min. QX-314 had no effect. N=10 mice per group. Data are mean±SD. Asterisk indicates P<0.05. (c) Plantar pinprick responses in naïve male mice after perisciatic injection of 0.5% lidocaine, 0.5% QX-314 or 0.5% BW-031. Lidocaine produces robust block of pinprick response in naïve mice at 5 min with recovery at 60 min. Neither QX-314 nor BW-031 had any effect. N=8 mice per group. Data are mean±SD. Asterisks indicate P<0.05.