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. Author manuscript; available in PMC: 2021 Dec 4.
Published in final edited form as: Nat Struct Mol Biol. 2021 Oct 8;28(10):847–857. doi: 10.1038/s41594-021-00667-6

Extended Data Fig. 8 |. Membrane interface of K-Ras, Gal-3, and C-Raf.

Extended Data Fig. 8 |

a. Positively charged residues of a base-tier K-Ras protein proximal to the membrane in the signalosome model. The inset shows the direct interaction between the HVR lysines of a K-Ras protein at the base tier and the phosphotidylserine lipids. b. Positively charged residues and prolines of Gal-3 proximal to the membrane at the base tier. A Val126 residue that has been suggested to be involved in Gal-3 membrane interaction23 is also shown. c. Positively charged residues of the C-Raf RBD and CRD and the two CRD-bound Zn2+ ions proximal to the membrane.