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. 2021 Nov 30;15:4811–4825. doi: 10.2147/DDDT.S328238

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© 2021 Huang et al.

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OB inhibits RANKL-mediated osteoclastogenesis in vitro. (A) TRAP staining showed different concentrations of OB (10, 20, 30, 40, 50μM) inhibited osteoclast formation (upper: 200μm magnification, lower: 100μm magnification). (B) TRAP staining showed the time dependent effect of OB (50μM) on osteoclast formation, on day 1 of OB interference (sustaining until day 3), on day 3 of OB interference (sustaining until day 5) and OB interference on the entire duration (upper: 200μm magnification, lower: 100μm magnification). (C) TRAP-positive cells were quantified after administration of different concentrations of OB. (D) TRAP-positive cells were quantified after administration in different time periods. *P < 0.05; **P < 0.01; ***P< 0.001.