Table 4.
GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) Enrichment Analysis Results of Down-Regulated DEGs
| Category | Term | Count | P value | Genes |
|---|---|---|---|---|
| GO_BP | Steroid metabolic process | 10 | 1.40E-09 | SULT1B1, CYP2C9, CYP3A7-CYP3A51P, AKR1B10, UGT2B15, AKR1C3, AKR1C2, CYP2C19, CYP3A5, SULT2A1 |
| GO_BP | Xenobiotic metabolic process | 12 | 1.72E-09 | NQO1, SULT1B1, CYP2C9, ALDH3A1, CYP3A7-CYP3A51P, AKR7A3, AADAC, AKR1C1, UGT2B15, CYP2C19, CYP3A5, CYP2C18 |
| GO_BP | Oxidation-reduction process | 26 | 2.99E-08 | HPGD, MAOA, HHIP, ADH7, CYP2C19, CYP2C18, LIPF, AKR7A3, RDH12, LDHD, NQO1, HGD, AKR1C1, CYP3A43, AKR1C3, AKR1C2, PTGR1, CYP4F12, FMO5, CYP2C9, ALDH3A1, FA2H, DHRS7, AKR1B10, ALDH1A1, GPD1L |
| GO_BP | Digestion | 10 | 4.80E-08 | CAPN8, CAPN9, AKR1B10, CCKBR, AKR1C1, GKN1, AKR1C2, SSTR1, PGC, SULT2A1 |
| GO_BP | Daunorubicin metabolic process | 4 | 8.53E-05 | AKR1B10, AKR1C1, AKR1C3, AKR1C2 |
| GO_CC | Extracellular exosome | 67 | 3.73E-08 | CLIC6, FCGBP, TREH, JCHAIN, SULT1C2, UPK1B, UBL3, AKR7A3, CA2, FAM3B, SH3BGRL2, TMEM38A, ENPP6, BCAS1, HGD, PLLP, ENTPD5, LIFR, RNASE4, PTGR1, RNASE1, PGC, MUC5AC, EPN3, ACE2, C1ORF116, SLC7A8, SCNN1B, CDHR2, ALDH1A1, ANG, ALDOB, FBP1, ASPA, GPRC5C, FBP2, LTF, SMIM24, CSTA, HPGD, TMPRSS2, IQGAP2, SLC9A1, PBLD, SELENBP1, ADGRG2, SCIN, COBLL1, PDGFD, METTL7A, GC, PROM2, NQO1, MGAM, GGT6, AKR1C1, AKR1C3, GUCA2B, RAB27A, RAB27B, GALE, AKR1B10, S100P, CYSTM1, GPD1L, SLC26A9, CCL28 |
| GO_CC | Organelle membrane | 11 | 9.94E-08 | FA2H, CYP2C9, CYP3A7-CYP3A51P, AADAC, CYP3A43, UGT2B15, CYP2C19, CYP4F12, CYP3A5, CYP2C18, FMO5 |
| GO_CC | Integral component of membrane | 93 | 1.38E-05 | KLB, HEPACAM2, ATP2A3, KLHDC7A, AQP4, CWH43, TMEM92, TMEM220, SMPD3, TMEM266, UPK1B, STS, VSIG1, FAM174B, DNER, CLDN23, CA9, TMEM38A, TMED6, PAQR8, CYP3A7-CYP3A51P, KCNK10, PLLP, DAPK2, ABCC5, CYP3A43, UGT2B15, LIFR, TMEM171, DISP1, SLC22A23, ACE2, ALDH3A1, SLC7A8, RNF128, CCKBR, B3GNT6, NRG4, SCNN1B, MAL, ADTRP, VSTM2A, GPRC5C, SIDT2, GRAMD1C, SMIM24, SMIM5, KCNE2, MYRF, MAOA, SLC41A2, STX19, PELI2, ETFDH, TMPRSS2, ADRB2, SMIM6, CYP3A5, SLC9A1, MFSD4A, ADAM28, ADGRG2, GCNT2, TNFRSF17, SPTSSB, GPAT3, METTL7A, B4GALNT3, PROM2, SLC14A1, NQO1, MGAM, GGT6, FER1L4, TRPA1, ABCA5, STYK1, KCNJ15, KCNJ16, ABCA8, LRRC66, FMO5, CYP4F12, FA2H, ATP4A, XK, AADAC, TMEM116, PXMP2, ATP13A4, CYSTM1, SLC26A9, MRAP2 |
| GO_CC | Apical plasma membrane | 13 | 0.000236875 | MGAM, RAB27A, RAB27B, ADRB2, CYP4F12, SLC9A1, UPK1B, ADGRG2, SCNN1B, CDHR2, MAL, SLC26A9, PROM2 |
| GO_CC | Basolateral plasma membrane | 10 | 0.000359953 | SLC14A1, HPGD, SLC7A8, CA2, KCNJ16, CA9, AQP4, DISP1, SLC9A1, PROM2 |
| GO_MF | Oxidoreductase activity | 15 | 8.51E-08 | HPGD, ADH1C, MAOA, AKR1C1, AKR1C3, ETFDH, AKR1C2, ADH7, PTGR1, CYP2C19, CYP3A5, CYP2C9, ALDH3A1, DHRS7, ALDH1A1 |
| GO_MF | Retinol dehydrogenase activity | 5 | 4.65E-05 | RDH12, ADH1C, ADH1A, AKR1C3, ADH7 |
| GO_MF | Monooxygenase activity | 7 | 5.40E-05 | CYP2C9, CYP3A7-CYP3A51P, CYP3A43, CYP2C19, CYP4F12, CYP3A5, CYP2C18 |
| GO_MF | Oxygen binding | 6 | 0.000202147 | CYP2C9, CYP3A7-CYP3A51P, CYP2C19, CYP4F12, CYP3A5, CYP2C18 |
| GO_MF | Aromatase activity | 5 | 0.000246051 | CYP3A7-CYP3A51P, CYP3A43, CYP4F12, CYP3A5, CYP2C18 |
| KEGG | Chemical carcinogenesis | 12 | 9.25E-09 | CYP2C9, ALDH3A1, CYP3A7-CYP3A51P, ADH1C, ADH1A, CYP3A43, UGT2B15, ADH7, CYP2C19, CYP3A5, CYP2C18, SULT2A1 |
| KEGG | Metabolism of xenobiotics by cytochrome P450 | 11 | 5.41E-08 | CYP2C9, ALDH3A1, AKR7A3, ADH1C, ADH1A, AKR1C1, UGT2B15, AKR1C2, ADH7, CYP3A5, SULT2A1 |
| KEGG | Retinol metabolism | 10 | 1.83E-07 | CYP2C9, CYP3A7-CYP3A51P, RDH12, ADH1C, ADH1A, UGT2B15, ALDH1A1, ADH7, CYP3A5, CYP2C18 |
| KEGG | Drug metabolism-cytochrome P450 | 10 | 3.14E-07 | CYP2C9, ALDH3A1, ADH1C, MAOA, ADH1A, UGT2B15, ADH7, CYP2C19, CYP3A5, FMO5 |
| KEGG | Gastric acid secretion | 9 | 6.32E-06 | ATP4B, ATP4A, KCNE2, CCKBR, KCNK10, CA2, KCNJ15, KCNJ16, SLC9A1 |