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. 2021 Nov 30;16:7831–7846. doi: 10.2147/IJN.S334194

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© 2021 Wu et al.

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sEV could be controlled released from sEV-GelMA complex after preservation in vivo. (A) General view of different UV-crosslinking time for preserved GelMA-sEV complex (B) Viscosity of different UV-crosslinking time GelMA-sEV complex dressing with the shear rate from 0.1 to 10 1/s. (C) Rheological behavior of different UV-crosslinking time GelMA-sEV complex was evaluated via rheometer. The significance was tested with repeated measurement data analysis of variance (MANOVA). (D) General view and schematic view of the experimental operation in vivo. (E) Ex vivo visualization of red fluorescent labeled GelMA hydrogels UV-crosslinked by different time period for 6 days. (F) Ex vivo visualization of DiO labeled sEV encapsulated in GelMA hydrogels UV-crosslinked by different time period for 6 days. (G) Quantification analysis of the fluorescence intensity for red fluorescent labeled GelMA hydrogels and DiO labeled sEV with different crosslinking time. The correlation coefficient R and significance of Figure 5G was calculated by linear correlation analysis. (***p < 0.001).