Table 1.

Classification of therapeutic actions of somatostatin on HCC.

Level	Effect type	Mechanism	Reference
Cellular	Antiproliferative	MAP kinase pathway—G1 phase arrest	[41, 42]
		Other mechanisms (specific receptors)	[43]
		Trophic factor secretion inhibition	[39, 40]
	Apoptotic	p53-dependent	[44]
		p53-independent	[45, 46]
		Trophic factor secretion inhibition	[39, 40]
		Fas-Fas ligand expression increase	[47]
Systemic	Antineoplastic	Immune pathway modulation	[48]
		Reduction of oxidative stress	[49]
		Reduction of NO production	[50]
	Anti-inflammatory	Decrease of proinflammatory cytokine levels	[51]
		Potential direct effect on stellate cells	[52, 53]
		Reduction of Kupffer cell-related MMP activity	[43]