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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Nature. 2021 Aug 31;598(7881):451–456. doi: 10.1038/s41586-021-03920-6

Fig. 3 |. Alcohol scope for deoxygenative arylation.

Fig. 3 |

Primary, secondary and tertiary alcohols can be used as alkyl coupling partners in the arylation. All yields are isolated unless otherwise noted. Experiments typically run with 1.0 equivalent of aryl halide, 1.7 equivalent of alcohol and 1.6 equivalent of NHC salts on 0.5 mmol scale. *See Supplementary Information for experimental details. §Ni(TMHD)2 and methyl 4-bromobenzoate are used as the catalyst and aryl halide coupling partner, respectively. Boc, tert-butyloxycarbonyl; Bn, benzyl; Et, ethyl; PMB, 4-methoxybenzyl; Piv, pivaloyl; Ts, 4-toluenesulfonyl; Ni(TMHD)2, nickel(ii) bis(2,2,6,6-tetramethyl-3,5-heptanedionate).