Table 3.
Effects of free PTX and niosomal PTX on hematological parameters, biochemical parameters, and liver MDA content of different experimental groups
| Parameter | Treatment* | |||
|---|---|---|---|---|
| Control | Niosomal PTX 2.5 mg/kg | Niosomal PTX 5 mg/kg | Free PTX 2.5 mg/kg | |
| MDA(nmol/mg protein) | 201.7 ± 46.4 | 222.8 ± 27.4 | 245.7* ± 25.5 | 256.2** ± 34.5 |
| AST (U/L) | 148.8 ± 24.7 | 153.7 ± 31.5 | 175.3* ± 15.1 | 197.6*** ± 13.4 |
| ALT (U/L) | 38.8 ± 5.1 | 39.4 ± 5.0 | 49.6* ± 9.7 | 54.7*** ± 10.1 |
| BUN (mg/dL) | 14.1 ± 2.9 | 18.9* ± 3.8 | 20.4** ± 4.4 | 20.7** ± 4.2 |
| Creatinine (mg/dL) | 0.82 ± 0.12 | 0.91 ± 0.11 | 1.10* ± 0.20 | 1.20** ± 0.34 |
| Hemoglobin (g/dl) | 13.9 ± 1.4 | 14.6 ± 1.1 | 13.7 ± 2.1 | 14.7 ± 4.2 |
| Haematocrit (%) | 38.8 ± 8.4 | 41.0 ± 3.5 | 43.3 ± 6.3 | 40.2 ± 5.1 |
| RBC 106 Cells/mm3 | 6.7 ± 0.2 | 6.8 ± 0.21 | 6.6 ± 0.4 | 6.5 ± 0.6 |
PTX paclitaxel, AST aspartate aminotrasferase, ALT alanine aminotransferase, BUN blood urea nitrogen
*significant for control group (P < 0.05)
**significant for control group (P < 0.01)
***significant for control group (P < 0.001)