. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2021 Oct 7:10.1158/1055-9965.EPI-21-0675. doi: 10.1158/1055-9965.EPI-21-0675

Table 2.

Age- and multivariable-adjusted hazard ratios for the association between predicted vitamin D score and risk of colorectal cancer, overall and by cancer site, N=49,534.

Predicted vitamin D score	Overall colorectal cancer (n=488)				Colon cancer (n=370)			Rectal cancer (n=105)
Predicted vitamin D score	Cases	Person-years	Age-adjusted HR (95% CI) ^a	MV-adjusted HR (95% CI) ^b	Cases	Age-adjusted HR (95% CI) ^a	MV-adjusted HR (95% CI) ^b	Cases	Age-adjusted HR (95% CI) ^a	MV-adjusted HR (95% CI) ^b

Quartile 1 (Lowest)	147	254,671	1.57 (1.19–2.08)	1.41 (1.04–1.89)	116	1.63 (1.18–2.25)	1.44 (1.02–2.01)	29	1.38 (0.74–2.57)	1.34 (0.70–2.56)
Quartile 2	133	276,186	1.34 (1.01–1.78)	1.23 (0.92–1.65)	98	1.30 (0.93–1.80)	1.17 (0.83–1.64)	30	1.38 (0.75–2.55)	1.34 (0.71–2.52)
Quartile 3	133	280,223	1.34 (1.01–1.78)	1.26 (0.95–1.68)	99	1.31 (0.95–1.82)	1.22 (0.88–1.71)	30	1.39 (0.75–2.55)	1.35 (0.73–2.50)
Quartile 4 (Highest)	75	206,819	1.00 (ref)	1.00 (ref)	57	1.00 (ref)	1.00 (ref)	16	1.00 (ref)	1.00 (ref)
P-trend			0.003	0.05		0.005	0.06		0.39	0.49

Hazard ratios adjusted for age and time period.

Hazard ratios adjusted for age, time period, family history of colorectal cancer, calcium supplementation, aspirin use, and processed meat consumption.

HR, Hazard ratio; CI, Confidence interval; MV, Multivariable.