Table 3.
Multivariable-adjusted hazard ratios for the association between predicted vitamin D score and risk of colorectal cancer, with additional control for variables that were included in the vitamin D prediction model.
| Predicted vitamin D score | Multivariable-adjusted hazard ratios (95% CI) a |
|||||||
|---|---|---|---|---|---|---|---|---|
| Adjusted for physical activity | Adjusted for smoking status | Adjusted for alcohol use | Adjusted for postmenopausal hormone Use | Adjusted for BMI | Adjusted for vitamin D supplementation | Adjusted for multivitamin use | Adjusted for all 7 vitamin D predictors | |
|
| ||||||||
| Quartile 1 (Lowest) | 1.43 (1.06–1.94) | 1.41 (1.04–1.90) | 1.44 (1.07–1.94) | 1.43 (1.06–1.92) | 1.39 (1.01–1.90) | 1.46 (1.08–1.98) | 1.46 (1.07–2.00) | 1.62 (1.13–2.33) |
| Quartile 2 | 1.25 (0.93–1.68) | 1.23 (0.92–1.65) | 1.24 (0.92–1.67) | 1.24 (0.92–1.66) | 1.22 (0.90–1.65) | 1.27 (0.94–1.71) | 1.25 (0.93–1.69) | 1.35 (0.98–1.86) |
| Quartile 3 | 1.27 (0.95–1.70) | 1.26 (0.95–1.68) | 1.27 (0.95–1.69) | 1.26 (0.95–1.69) | 1.26 (0.94–1.68) | 1.29 (0.96–1.73) | 1.27 (0.95–1.69) | 1.33 (0.99–1.79) |
| Quartile 4 (Highest) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| P-trend | 0.04 | 0.05 | 0.03 | 0.04 | 0.08 | 0.03 | 0.03 | 0.02 |
a
Hazard ratios also adjusted for age, time period, family history of colorectal cancer, calcium supplementation, aspirin use, and processed meat consumption.
CI, Confidence interval; BMI, Body mass index.