. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2021 Oct 7:10.1158/1055-9965.EPI-21-0675. doi: 10.1158/1055-9965.EPI-21-0675

Table 4.

Multivariable-adjusted hazard ratios for the association between predicted vitamin D score and risk of colorectal cancer within strata of age. ^a

	Age <50 years			Age ≥50 years
Predicted vitamin D score	Cases	Person-years	MV-adjusted HR (95% CI) ^b	Cases	Person-years	MV-adjusted HR (95% CI) ^b

Quartile 1 (Lowest)	35	145,622	1.31 (0.72–2.38)	112	109,049	1.44 (1.02–2.03)
Quartile 2	37	162,467	1.33 (0.74–2.39)	96	113,719	1.20 (0.85–1.68)
Quartile 3	39	166,919	1.47 (0.83–2.62)	94	113,304	1.19 (0.85–1.67)
Quartile 4 (Highest)	17	118,994	1.00 (ref)	58	87,825	1.00 (ref)
P-trend			0.65			0.04

P-interaction=0.73

Hazard ratios adjusted for age, time period, family history of colorectal cancer, calcium supplementation, aspirin use, and processed meat consumption.

MV, Multivariable; HR, Hazard ratio; CI, Confidence interval