. Author manuscript; available in PMC: 2021 Dec 5.

Published in final edited form as: Proc SPIE Int Soc Opt Eng. 2021 Feb 15;11596:115960D. doi: 10.1117/12.2582340

Table 3.

Pearson’s correlation coefficient between volume loss between two time-points and the TMS decline during the same time period. Bold numbers denote the method identifying a stronger correlation. We observe that some structures like the thalamus show weak correlations with both methods, in line with the existing HD literature. Note that subjects with missing TMS data were excluded from this analysis (n=3, 2, 2 for high-CAP, medium-CAP and low-CAP categories respectively).

All HD Subjects (low-CAP, med-CAP, high-CAP)
	R thalamus	L thalamus	R caudate	L caudate	R pallidum	L pallidum	R putamen	L putamen
Cross-sec.⁸	−0.1985	−0.0232	−0.3800	−0.2826	−0.3233	−0.4280	−0.3750	−0.3431
Longitudinal	−0.1345	0.0743	−0.3809	−0.3654	−0.3712	−0.4587	−0.3152	−0.3482
Low-CAP Subjects
	R thalamus	L thalamus	R caudate	L caudate	R pallidum	L pallidum	R putamen	L putamen
Cross-sec.⁸	−0.0639	−0.2707	−0.2342	−0.1888	−0.4166	−0.2540	−0.2987	−0.4645
Longitudinal	−0.0840	−0.2680	−0.2764	−0.2871	−0.4079	−0.3044	−0.2922	−0.4730
Med-CAP Subjects
	R thalamus	L thalamus	R caudate	L caudate	R pallidum	L pallidum	R putamen	L putamen
Cross-sec.⁸	−0.1258	0.3095	−0.3268	−0.2676	−0.3877	−0.4911	−0.3082	−0.3169
Longitudinal	−0.1034	0.4050	−0.3270	−0.3185	−0.4349	−0.5535	−0.2327	−0.4000
High-CAP Subjects
	R thalamus	L thalamus	R caudate	L caudate	R pallidum	L pallidum	R putamen	L putamen
Cross-sec.⁸	−0.5348	−0.2763	−0.627	−0.5513	−0.4162	−0.6226	−0.6836	−0.4264
Longitudinal	−0.3254	−0.0960	−0.6549	−0.6006	−0.6017	−0.6232	−0.5589	−0.3597