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In the ARC, 5-HT inhibits AgRP neuronal activity and reduces inhibitory synaptic output to POMC neurons, while activating POMC neurons increases α-MSH release. Both AgRP and POMC neurons project from the ARC to the DRN. In the DRN, α-MSH inhibits MC4R neurons, leading to reduced food intake and 5-HT levels, resulting in anxiety and depressive-like behavior.
