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. 2021 Oct 14;224(11):1821–1829. doi: 10.1093/infdis/jiab509

Figure 1.

Figure 1.

Coronavirus disease 2019 (COVID-19) disease severity and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load across age groups. A, Age of pediatric patients with SARS-CoV-2 infection, stratified by disease severity: asymptomatic (n = 27), mild disease, outpatient (n = 48), or moderate/severe COVID-19, hospitalized (n = 18). Analyzed by ordinary 1-way analysis of variance (ANOVA). B, SARS-CoV-2 viral load was quantified across a range of disease severities. Patients presenting with <10 days of symptoms were compared, including asymptomatic pediatric outpatients (n = 27), mildly symptomatic pediatric outpatients (n = 44), moderate/severe pediatric hospitalized patients with oxygen requirement (n = 18), and moderate/severe adult hospitalized patients (n = 29). Analyzed by ordinary 1-way ANOVA. C, Correlation of viral load and age, stratified by asymptomatic (n = 30), mild outpatient (n = 48), and moderate/severe hospitalized (n = 18) cohorts. Analyzed by Pearson correlation. D, Viral load of hospitalized adults (n = 29), hospitalized pediatric participants requiring respiratory support (n = 18), and pediatric outpatients with mild disease (n = 48), plotted against duration of symptoms. Dotted lines depict limit of detection. Analyzed by simple linear regression, comparison of slopes. ∗P < .05, ∗∗P < .01; ∗∗∗P < .001, ∗∗∗∗P < .0001; ns = not significant.