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. 2021 Nov 20;224(11):1861–1872. doi: 10.1093/infdis/jiab535

Figure 2.

Figure 2.

SARS-CoV-2 seroconversion in macaques. A, Study design. B, IgM, IgG, and IgA antibody responses specific for SARS-CoV-2 spike protein (S1+S2) in plasma collected at 0, 3, 7, 14, and 21 dpi measured using ELISA. Fold change in IgM, IgG, and IgA antibody responses determined by dividing with the values measured at 0 dpi (1-way analysis of variance with Dunnett test for multiple comparisons vs 0 dpi; ∗P<.05, ∗∗P<.01, ∗∗∗∗P<.0001). Data are presented as mean ± SEM. C, Neutralization was determined according to the plasma dilution at the indicated dpi. The SARS-CoV-2 plaque reduction was 50%. Abbreviations: CM, cynomolgus macaque; dpi, days postinfection; ELISA, enzyme-linked immunosorbent assay; ELISPOT, enzyme-linked immunospot; FACS, fluorescence-activated cell sorting; Ig, immunoglobulin; LN, lymph node; OD, optical density; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.