Table 2.
Variables Associated With Infant Baseline HIV DNA Level, a Post-LASSO Multivariate Analysis
| All Infants (n = 164) | PoC Infants (n = 77) | DBS Infants (n= 87) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | β | 95% CI | P Valuea | β | 95% CI | P Valuea | β | 95% CI | P Valuea |
| Infant plasma viral load, log10 HIV RNA copies/mL | .22 | .14 to .3 | <.0001 | .22 | .09 to .35 | .001 | .26 | .17 to .35 | <.0001 |
| Infant CD4, % | −.03 | −.04 to −.02 | <.0001 | −.01 | −.04 to .01 | .2 | −.03 | −.04 to −.02 | <.0001 |
| No antenatal cART | .61 | .24 to .98 | .002 | .76 | .13 to 1.39 | .02 | … | … | … |
| Male infant | … | … | … | −.49 | −.88 to −.09 | .02 | … | … | … |
| Acute maternal infection | … | … | … | .29 | −.08 to .66 | .1 | … | … | … |
| Infant CD4:CD8 | … | … | … | −.08 | −.28 to .11 | .4 | … | … | … |
| Maternal age, y | … | … | … | … | … | … | −.02 | −.04 to 0 | .03 |
Adjusted r2 all infants = 0.37 (P ≤ .0001); PoC infants = 0.39 (P ≤ .0001); DBS infants = 0.5 (P ≤ .0001).
Abbreviations: β, unstandardized regression coefficient estimate; cART, combination antiretroviral therapy; CI, confidence interval; DBS, dried blood spot tested; HIV, human immunodeficiency virus; PoC, point-of-care tested.
a P values for post-LASSO linear regression models should be interpreted with caution as they ignore the selection by LASSO.