Fig. 4.

Changes in the expression of genes implicated in blood-brain barrier (BBB) function in adenocarcinoma brain metastasis (BM) vasculature. (A-C) Differential expression of selected genes linked to brain vasculature development and BBB function in BM vasculature. The selected gene list was generated as described in Figure 2. Upregulated genes are in red, downregulated genes are in blue. White box—no change in gene expression between the BM and normal brain vessels. *Black box—the P value was not calculated by DESeq2. The log₂ fold changes for these genes are: SLC43A2—2.14, SLC16A6—3.26, SLC16A10—4.52, SLC28A1—4.27, CEACAM3—2.13, ICAM1—0.93, TICAM1—1.03, CCL25—not applicable.