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. 2021 Jul 19;30(24):2429–2440. doi: 10.1093/hmg/ddab206

Figure 3 .

Figure 3

WNT2 is expressed in the normal intestinal epithelium and adenocarcinomas of the deletion carriers. (A-F) RNA in situ hybridization of CFTR (green) and WNT2 (red) in normal intestinal epithelium and tumors of a deletion carrier and a sporadic patient. The nuclei are stained with DAPI (blue). Identical image settings were used for the compared tissue types. Following signal intensity settings were used: DAPI 90, Cy3 150 and Cy5 30 (A, B), DAPI 90, Cy3 150, Cy5 30 (C, D), DAPI 80, Cy3 90 and Cy 50 (E, F). A, Normal small intestinal epithelium of a deletion carrier and b, a sporadic patient shows uniform expression of CFTR. A,  WNT2 is expressed only in the intestinal epithelium of the deletion carrier. C, Small intestinal neuroendocrine tumor of a deletion carrier and D, a sporadic patient displays no expression of CFTR or WNT2. E, Colorectal adenocarcinoma of a deletion carrier and F, a sporadic patient show uniform expression of CFTR. E, WNT2 expression is present only in the adenocarcinoma of the deletion carrier.