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. 2021 Nov 26;49(21):12017–12034. doi: 10.1093/nar/gkab1145

Figure 3.

Figure 3.

Schematic structural representation of Pol III. (A) Comparison of subunit compositions of Pol II and Pol III (yeast and human) with emphasis on the built-in transcription factors (BITFs) of Pol III. The human gene nomenclature is provided for the homologs under the column headed by HUGO. Note that humans have two alternate isoforms of RPC7 encoded by POLR3G and POLR3GL. (B) A structure model of human Pol III based on cryo-EM, modeled after Girbig et al. (51). HE expansion refers to the extra purple globular domain of RPC5 attached by a linker (dashed line) which is specific to higher eukaryotes. The subunits targeted by mutations found in VZV-susceptible patients (10) or in yeast-two hybrid studies for DSB repair (11) are indicated as discussed in the text indicated by arrows. Numbers in parentheses indicate the percentage of POLR3-unique VZV-susceptible alleles identified have been reported to date in the designated gene. (C) As in (B). the structure of Pol III is shown but with yeast nomenclature. The BITFs are indicated as such.