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HAT1 is required to maintain nuclear structure and stability. (A) HAT1+/+ (n = 12 980) and HAT1−/− (n = 11 796) cells were stained with DAPI, imaged and nuclear area determined with ImageJ. (B) Cells of the indicated genotype were visualized with DAPI. The percentage of cells containing nuclear blebs or micronuclei (marked by white arrows) was quantitated (n = 1207 and 894 cells for HAT1+/+ and HAT1−/−, respectively, *P-value < 0.05).
