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. 2021 Nov 18;49(21):12540–12555. doi: 10.1093/nar/gkab936

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Terminal Hoogsteen base pairs. (A and B) Comparison of 2mF_o-DF_c and mF_o-DF_c electron density maps for the Watson–Crick (left) and the corresponding Hoogsteen models (right) for (A) a G-C terminal bp in Homing endonuclease I-Onul and (B) a A-T terminal bp in Esp1396I. Electron density meshes and stereochemistry are as described in Figure 1C and the box scheme is as described in Figure 2A. A complete set of data is provided in Supplementary Figures S6 and S7. (C) An example of crystal stacking interactions in a terminal Hoogsteen bp.