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. 2021 Sep 23;49(21):e123. doi: 10.1093/nar/gkab791

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Metabolic design for enhanced lycopene production in Synechocystis. The lycopene overproduction construct encodes four enzymes shown in pink. Native metabolism of Synechocystis is shown in black. DXS (1-deoxy-d-xylulose 5-phosphate synthase) catalyses the synthesis of 1-deoxy-d-xylulose 5-phosphate from pyruvate and glyceraldehyde 3-phosphate. GGPP (Geranylgeranyl diphosphate) is synthesised by CrtE (Geranylgeranyl diphosphate synthase) which catalyses the condensation between FPP (Farnesyl diphosphate) and IPP (Isopentenyl diphosphate). CrtB (phytoene synthase) then catalyses the condensation of two GGPP molecules to generate phytoene. Finally, CrtI (phytoene desaturase) catalyses the synthesis of lycopene (shown in red box) from phytoene, bypassing the native two-enzyme desaturation pathway (CrtP and CrtQ) via ζ-carotene.