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. 2021 Nov 25;49(21):12377–12393. doi: 10.1093/nar/gkab1123

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Enhanced dynamics also observed in longer telomeric overhang. (A, B) The representative real time smFRET traces of TRF2 binding at telomeric duplex (flow at ∼10 s) to the pre-bound POT1 of 6R (A) and 8R (B) overhangs. (C, D) The heatmap (n > 100) of POT1 bound state in absence (top) and presence (bottom) of TRF2 (flow at ∼10 s) of 6R (C) and 8R (D) overhangs. (E) FRET heatmap histograms generated from the dynamic traces of POT1 only and POT1 followed by TRF2 addition to 2R, 4R, 6R and 8R overhangs containing telomeric duplex (keeping the bin size 0.2). (F) Proposed model of TRF2 induced POT1 overhang dynamics of the respective construct.