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POT1 bound overhangs show discrete steps moving up and down along the TRF2 bound duplex. (A, D) Representative smFRET traces (blue) fitted by HMM (red), (B, E) transition density plot (TDP) and, (C, F) the proposed models of POT1 bound 4R, 6R and 8R telomeric overhangs moving up and down to the TRF2 bound four (A–C) and two (D–F) repeats of TTAGGG containing duplex.
