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. 2021 Nov 25;49(21):12377–12393. doi: 10.1093/nar/gkab1123

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Telomeric duplex bound TRF2 delays POT1 binding to telomeric overhangs. (A) Schematic model of telomeric duplex (four repeats of TTAGGG tract) with the G4/4R overhang, sequentially binding TRF2 at the duplex followed by POT1 at the overhang. (B) The FRET histograms of telomeric duplex with 4R overhang (top), TRF2 bound condition (second from top), and POT1 binding at 3 and 20 min, respectively (bottom two). (C) Single-exponential fitting of POT1 bound fraction in the absence and presence of TRF2. (D) The bar graph represents the corresponding POT1 binding rate in the absence and presence of TRF2 of different overhang. All statistics for this figure are calculated using a two-tailed two-sample Student's t test (ns, not significant; *P < 0.05; **P < 0.01).