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Proposed dynamic model of POT1 and POT1 with TRF2 bound to telomeric DNA. (A) POT1 bound telomeric overhang showing dynamics. (B) TRF2 recruit POT1 bound 3′ end towards the junction and moving up and down along the duplex axis. (C) TRF2ΔB doesn’t recruit POT1 bound 3′ end towards the junction. (D) Shelterin components bridging interactions within the proteins bound at telomeric DNA.
