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Proposed mechanisms of TAF- and INSTI-mediated excess weight gain. All proposed mechanisms warrant further study for confirmation, and the explanation may be multifactorial. Abbreviations: ART, antiretroviral therapy; EFV, efavirenz; INSTI, integrase strand transfer inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitor; NRTI, nucleoside reverse transcriptase inhibitor; TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate.
