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. 2021 Dec 4;19:402. doi: 10.1186/s12951-021-01145-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Construction of ultrasound controllable smart exosome-based system for Bmp7 targeting delivery. A Schematic illustration of exosome-based Bmp7 delivery system SmartExo@Bmp7 construction. B Schematic illustration of comparison of delivery efficiency of Exo@Bmp7 and SmartExo@Bmp7. C qPCR analysis of relative expression level of Bmp7 in exosomes isolated from control and BMP7 transfected 293T cells (Exo@Bmp7) and SmartExo@Bmp7. D Relative expression of Bmp7 mRNA in various organs. Mice were treated with Exo@Bmp7 and SmartExo@Bmp7 and additionally treated with ultrasound irradiation in the abdominal region. Data are expressed as mean ± SEM, n = 3, *p< 0.05, ***p < 0.001