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. 2021 Dec 4;16:24. doi: 10.1186/s13062-021-00312-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — YY1 transcriptionally activates LOXL1-AS1 transcription in HCC cells. A UCSC database showed the possible transcription factors for LOXL1-AS1. B qRT-PCR analysis was done for the measurement of YY1 and LOXL1-AS1 levels in cells with transfection of sh/YY1 and pcDNA3.1/YY1. C, D DNA motif of YY1 and the binding sites of YY1 and LOXL1-AS1 promoter were obtained from JASPAR database. E ChIP assay proved the binding correlation between YY1 and LOXL1-AS1 promoter. F Luciferase reporter assay confirmed the binding of YY1 and LOXL1-AS1 promoter and detected the exact binding site. **P < 0.01